exsulin—Targeting the Root Cause of Diabetes

Diabetes is caused by loss of insulin secretion. For people with T1 diabetes (T1DM), this loss is virtually total and insulin therapy is mandatory. For those with T2 diabetes (T2DM), this loss is progressive and many people with T2DM eventually require insulin therapy. To cure both forms of diabetes will require restoring normal insulin secretion. Many different ways of restoring normal insulin secretion are being pursued— including islet transplantation, stem cell therapies, and even the artificial pancreas.These approaches involve major challenges and likely are many years from becoming generally available, if ever. Perhaps a more feasible approach is to utilize molecules that cause insulin-secreting tissue to regenerate from precursor cells, similar the development of the pancreas before birth. exsulin Corporation aims to develop therapies that restore insulin secretion in all insulin-requiring people. exsulin is also the brand name for a synthetic portion of a naturally occurring protein, islet neogenesis associated protein (INGAP). INGAP appears to be involved in the regulation of pancreatic islets—the tissue that contain insulin secreting beta cells.

History of exsulin’s Discovery and Development

In the search for a natural substance that could stimulate islet regeneration, Dr. Lawrence Rosenberg of McGill University discovered that an animal pancreas abstract contained the ability to make islet-like tissue develop. From this extract, Dr. Rosenberg, Dr. Arthur Vinik at Eastern Virginia Medical School, and their colleagues isolated and identified the molecule responsible for regeneration activity and named it islet neogenesis associated protein (INGAP). INGAP peptide was then identified as the smaller part within INGAP that carries the regeneration activity. INGAP peptide was then chosen as the molecule to be developed as a therapy for diabetes. INGAP Peptide—now branded as exsulin—has since been tested in multiple animals. These studies have shown that Exsulin not only stimulates islet regeneration, but improves or normalizes glucose control. Exsulin has also shown evidence of restored insulin secretion and improved glycemic control in two clinical trials of about 200 people with either T1DM or T2DM

With the availability of modern insulin therapy, why is exsulin needed?

Any person who uses insulin therapy knows the challenges involved. The basic problem is that achieving normal glucose levels with insulin therapy carries a large risk of serious insulin reactions (low glucose levels). exsulin is intended to be a means of reducing or ending dependence on insulin therapy so that risks of diabetic complications and serious hypoglycemia can be reduced and quality of life can be enhanced.



for people
///with diabetes